Microneedle based electrochemical (Bio)Sensing: Towards decentralized and continuous health status monitoring
نویسندگان
چکیده
Microneedle (MN) based electrochemical (bio)sensing has become a growing field within the discipline of analytical chemistry as result its unique capacity for continuous, decentralized health status monitoring. There are two significant advantages to this exclusive feature: i) ability directly analyze interstitial fluid (ISF), body with similar enough composition plasma (and blood) be considered plentiful source information related biologically relevant molecules and biomarkers; ii) overcome some major limitations blood analysis including painful extraction, high interferant concentrations, incompatibility diagnosis infants especially newborns). Recent publications have demonstrated important advancements in MN sensor technology, among which included new fabrication methods various modification strategies, providing different architectures allowing integration electronics. This versatility highlights undeniable need interdisciplinary efforts towards tangible progress field. In context evidently dominated by glucose sensing, is slowly being expanded other analytes, following crucial questions arise: what extent (bio)sensors reliable tool continuous ISF monitoring? Which best calibration protocol followed vivo assays? strategies can employed protect sensing element during skin penetration? Is there an appropriate validation methodology assess accuracy (bio)sensors? How distinction between successful achievements laboratory real commercial feasibility products? paper aims reflect on those previous while reviewing last decade focus aspects. Overall, we describe current state (bio)sensors, benefits challenges associated monitoring, well key features bottlenecks) regarding implementation assays.
منابع مشابه
Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays.
The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire micro...
متن کاملElectrochemical biosensing based on universal affinity biocomposite platforms.
Rigid conducting biocomposites are versatile and effective transducing materials for the construction of a wide range of amperometric biosensors such as immunosensors, genosensors and enzymosensors, particularly if the transducer is bulk-modified with universal affinity biomolecules. The strept(avidin)-graphite-epoxy biocomposite could be considered as an universal immobilization platform where...
متن کاملTowards a continuous monitoring of evapotranspiration based on MSG data
In the framework of the EUMETSAT’s Land Surface Analysis– Satellite Application Facility (LSA–SAF), a method was developed to estimate evapotranspiration (ET) over Europe. The methodology follows a Soil Vegetation Atmosphere Transfer (SVAT) approach. LSA–SAF provides main forcings deduced from Meteosat Second Generation (MSG): visible and infrared surface radiative fluxes and daily surface albe...
متن کاملOnline and in situ monitoring of environmental pollutants: electrochemical biosensing of cadmium.
Online sensitive monitoring of gene expression is essential for understanding microbial life and microbial communities, especially under stress-inducing conditions, such as the presence of environmental pollutants. We describe here a novel use of promoter-based electrochemical biosensing for online and in situ monitoring of gene expression in response to pollutants. As a model system, we used a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Analytical Chemistry
سال: 2021
ISSN: ['1879-3142', '0165-9936']
DOI: https://doi.org/10.1016/j.trac.2020.116148